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Jacketed Liposome Extruder
  • Jacketed Liposome Extruder
  • Jacketed Liposome Extruder
    • Liposome Extruder

    Jacketed Liposome Extruder

    Designed for liposome formulation and lipid nanoparticle preparation in laboratory and pilot-scale drug research and development

    ATS jacketed liposome extruder is professional equipment for liposome and nanoparticle preparation for laboratory and pilot-scale productions. The extruder’s core feature lies in the integrated jacketed temperature-control system, ensuring precise and stable temperature throughout the extrusion process. It is particularly suitable for temperature-sensitive samples.

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    Product Specifications
    Models NF-1 AE-001 AE-100 AE-500 AE-800
    Max. Sample Size (ml) 1 10 100 500 800
    Min. Sample Size (ml) 0.1 2 10 100 200
    Power Mode Hand drive/compressed air Compressed air Compressed air Compressed air Compressed air
    Thermo Control Water bath heating Jacketed Jacketed Jacketed Jacketed
    Working Temperature (℃) 5-80 5-80 5-80 5-80 5-80
    Filter Membrane Diameter (mm) 19 25 47 90 90
    Features
    • All component materials, including O-rings and gaskets, are FDA certified
    • All wetted parts are built with 316L stainless steel
    • Built-in pressure safety valve with a maximum working pressure up to 1000 psi
    • Complies with GMP standards and can be used in cleanrooms
    • Flexible single or dual assembly configurations
    • Easy assembly and disassembly for convenient cleaning and sterilization
    • Capable of processing high-concentration samples
    • Equipped with a temperature control system before and after extrusion to maintain a stable temperature environment
    • Membrane contact surfaces are electropolished to 1.5 Ra, far above the standard requirements
    Working Principle
    Working Principle

    The multilamellar liposome suspension is repeatedly extruded through the polycarbonate membranes with predefined pore sizes to produce unilamellar liposomes and nucleic acid. The multi-compartment samples are forced through the membranes by extrusion force to form a uniform, smaller liposomes ranging from 50–1000 nm.
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    The laboratory liposome extruder uses a jacketed temperature-control system (NF-1 model uses water-bath heating) to maintain a stable sample temperature between 5–80°C. Temperature control is applied both before and after extrusion to prevent thermal fluctuation and ensure sample stability for temperature-sensitive samples.

    All wetted pipelines are made of 316L stainless steel with 1.5 Ra electropolished surfaces, and FDA-certified components (e.g., O-rings), ensuring high cleanliness, easy sterilization, and virtually no dead-volume or cross-contamination.

    The jacketed extrusion is equipped with a built-in pressure safety valve (up to 1000 psi) that maintains constant pressure during repeated extrusion through polycarbonate membranes. The 316L stainless-steel pipelines and mirror-polished filter plates reduce material retention, ensuring high extrusion efficiency and liposome uniformity between 50–1000 nm.