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Online Liposome Extrusion System
  • Online Liposome Extrusion System
  • Online Liposome Extrusion System
    • Liposome Extruder

    Online Liposome Extrusion System

    Integrating multiple liposome extruders into a single system for continuous liposome extrusion in pilot and GMP-scale pharmaceutical production

    This online liposome extruder is a high-throughput extrusion system developed to meet the large-scale GMP requirements of liposome production. The core extrusion plate is made of sanitary-grade 316L stainless steel that complies with FDA and GMP standards, containing laser-drilled micro-sized pores as membrane supports. This extruder can be integrated with manual pumps, electric pumps, high-pressure homogenizers, or air pumps, operating at pressures from 1500–5000 psi. It is mainly used in the homogenization of pharmaceutical-grade liposomes, emulsions, and nanoparticles, used with a track-etched filter membrane with pore sizes of 50–400 nm. This extruder can be used to produce formulations of doxorubicin, paclitaxel, amphotericin B, daunorubicin, cytarabine, vincristine, cisplatin, and econazole nitrate liposomes.

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    Product Specifications
    Models EX01 EX05 EX10 EX-50 EX-100
    Working Pressure (psi) 0-4500 0-4500 0-4500 0-7500 0-7500
    Capacity Laboratory online type Pilot-scale Industrial-scale Industrial-scale Industrial-scale
    Membrane Filter Diameter (mm) 47 90 142 142 293
    Features
    • All component materials, including O-rings and gaskets, are FDA certified
    • Wetted part contact pipelines are made of 316L stainless steel
    • GMP-compliant, suitable for cleanroom use
    • Support CIP and SIP cleaning
    Working Principle
    Working Principle

    The online liposome extrusion system works by repeatedly passing multilamellar liposome suspensions through polycarbonate membranes with predefined nanopores, producing unilamellar liposomes and nucleic acids in uniform and smaller particles.

    Cases
    • Online Liposome Extrusion System
    • Online Liposome Extrusion System
    • Online Liposome Extrusion System
    Our Liposome Extruder
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    The online liposome extrusion system enables continuous processing, providing higher throughput and better consistency than traditional batch extrusion. It reduces manual handling, shortens processing time, and helps maintain stable liposome size distribution during long production runs.

    Yes. The online liposome extrusion system is designed to connect directly with upstream mixing, homogenization, or formulation tanks, forming a continuous processing line. This integration reduces intermediate storage and transfers, improving efficiency and reducing contamination risks.

    By precisely controlling flow rate, pressure, membrane configuration, and temperature, the online extrusion system maintains consistent operating conditions. This allows the liposomes to achieve and maintain a steady-state particle size distribution, ensuring stable product quality over extended production periods.